Major Depressive Disorder: 2025 CANMAT Treatment Guideline
The 2025 CANMAT guideline updates first-, second-, and third-line treatments for major depressive disorder (MDD), emphasizing measurement-based care, sequenced treatment, and the growing role of ketamine, esketamine, and augmentation strategies for treatment-resistant depression.
Updated 2025-03-15 · Reviewed for clinical accuracy
What is major depressive disorder?
First-line treatment
Treatment-resistant depression
Special populations
Practical takeaway
In short
“Major Depressive Disorder: 2025 CANMAT Treatment Guideline” is part of iMedCompanion’s plain-language library for international patients travelling to China for care. It explains what usually happens, what to prepare, and where to find related specialists and hospitals.
Key facts
Published in English
Reading time shown on every guide
Links to related specialists and hospitals
Reviewed for clinical accuracy
Frequently asked questions
Is this guide medical advice?
No. It explains what usually happens so you can ask better questions; decisions are made with your own specialist.
Can I get the guide in Chinese?
The guides are published in English; interpretation and translation are arranged as a separate service.
How do I find a specialist for this?
Each guide links to related specialists and hospitals, or you can send an enquiry and a medical advisor will match you.
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